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Tom Sutcliffe discusses evolution and extinction with Jules Pretty, who's been travelling to meet "enduring people in vanishing lands" and is concerned about their future; with Andreas Wagner on solving what he calls evolution's greatest puzzle - how can random mutations over a mere 3.8 billion years solely be responsible for eyeballs; poet Ruth Padel on what we can learn from animals and Chris Stringer who's been looking at ancient human occupation of Britain and how homo sapiens may have driven other humans to extinction.

Tom Sutcliffe explores our relationship with computer technology and the interplay of alien and familiar in science fiction. Tom's joined in the studio by writer William Gibson, novelist Michel Faber, LSE Professor Judy Wajcman and historian Dominic Sandbrook. How have computer technologies transformed our sense of outer space, cyber space and our own inner space?Producer: Simon Tillotson.

Self-portraits rarely fail to compel, but to what extent are they a true form of self-examination? James Hall maps the history of self-portraiture, from the earliest myths of Narcissus to the prolific self-image-making of contemporary artists. Rembrandt's self-portraits are the highlight of a major exhibition of the artist's work at The National Gallery. Its curator Betsy Wieseman discusses what these paintings can tell us about the artist. Poetry and memoir are the tools of John Burnside's self-exploration. A previous TS Eliot prize winner, he discusses his latest collection 'All One Breath' for which he has been nominated again this year. The musician Richard Tognetti argues that 'the self' can still shine through in interpretations of great classical works.Producer: Fiona Woods.