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Andrew Marr explores the limits of science and art in this week's Start the Week. The philosopher and neuroscientist Raymond Tallis mounts an all-out assault on those who see neuroscience and evolutionary theory as holding the key to understanding human consciousness and society. While fellow scientist Barbara Sahakian explores the ethical dilemmas which arise when new drugs developed to treat certain conditions are used to enhance performance in the general population. And the gerontologist Aubrey de Grey looks to the future when regenerative medicine prevents the process of aging. Producer: Katy Hickman.

Andrew Marr talks to Tim Harford about the key to success. The 'undercover economist' argues that the fear of failure paradoxically leads to greater and more dangerous failures - from oil disasters to world conflict. Success in parliament is often mercurial, but the new Director of the Institute for Government and former Labour Minister, Andrew Adonis believes the pool of talent for the top jobs is too small, and that Ministers should be better prepared for their role. Priyamvada Gopal argues that university education is becoming one of the country's biggest failures. She believes the humanities have been denigrated, as consecutive governments have emphasised the value of work, over knowledge. And Eli Pariser explores the world of internet personalisation in which your every move is tracked and individual choices assessed: he warns that it's the end of objective news and the free exchange of ideas. Producer: Katy Hickman.

Andrew Marr talks to Richard Sennett about increasing urbanisation. With half the world's population living in major cities, Sennett asks why the art of designing cities has declined so drastically in the last century. Iain Sinclair turns a critical eye on the grand plans for London's 2012 Olympics, and asks what will happen when the last race is run. Kate O'Regan was appointed as a judge in the Constitutional Court in South Africa by Nelson Mandela when he became President in 1994. She reflects on the role of the judiciary in building a modern democracy. And the advertising guru, John Hegarty reveals how you sell someone something they didn't even know they wanted. Over the last four decades he has transformed brands, famously linking Vorsprung durch Technik to Audi, and in a stroke, changing the perception of a staid car. Producer: Katy Hickman.